Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target
نویسندگان
چکیده
منابع مشابه
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Type III secretion systems: the bacterial flagellum and the injectisome.
The flagellum and the injectisome are two of the most complex and fascinating bacterial nanomachines. At their core, they share a type III secretion system (T3SS), a transmembrane export complex that forms the extracellular appendages, the flagellar filament and the injectisome needle. Recent advances, combining structural biology, cryo-electron tomography, molecular genetics, in vivo imaging, ...
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The assembly of the Yersinia enterocolitica type III secretion injectisome was investigated by grafting fluorescent proteins onto several components, YscC (outer-membrane (OM) ring), YscD (forms the inner-membrane (IM) ring together with YscJ), YscN (ATPase), and YscQ (putative C ring). The recombinant injectisomes were functional and appeared as fluorescent spots at the cell periphery. Epistas...
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Under certain conditions, pathogens like Yersinia secrete high levels of proteins. This ability correlates with cytotoxicity and virulence. The complete inactivity of the secreted proteins when added directly to host cells stimulated research to disclose this ‘‘non-AB toxin mechanism’’ of virulence, and eventually led to the discovery of the type III secretion mechanism and the ‘‘injection mode...
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ژورنال
عنوان ژورنال: EcoSal Plus
سال: 2019
ISSN: 2324-6200
DOI: 10.1128/ecosalplus.esp-0032-2018